The Effect of Polymorphism A/T 251 of the IL-8 Gene on Breast Cancer: A Systematic Review and Meta-Analysis

Breast cancer is the most common in women. In recent research works, role of cytokines development has attracted attention. Therefore, this paper intends to comprehensively assess association between breast and polymorphism A/T 251 from IL-8 gene using meta-analysis. study, find articles published electronically 2004 2020, national international databases SID, MagIran, Embase, ScienceDirect, Scopus, PubMed, Web Science (WoS). The odds ratio AA genotype patients with based was obtained as 1.42 (1.11–1.82: 95% confidence interval), which shows increasing effect by 0.42, AT on a meta-analysis studies 1.01 (0.84–1.22: demonstrates 0.01, TT similarly 0.95 (1.08–0.24: limit), decreasing 0.05. According meta-analysis, allele A significant relationship cancer, can be used predictor course disease clinical outcome cancer. Identifying gene, genetic marker predictor, also effective treating